Adipose TriGlyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL) protein expression is decreased in the obese insulin resistant state
نویسندگان
چکیده
1 Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands; 2 Inserm, U586, Obesity Research Unit, Toulouse, F-31432 France; 3 Paul Sabatier University, Louis Bugnard Institute, IFR31, Toulouse, F-31432 15 France; 4 CHU de Toulouse, Biochemistry Laboratory, Biology Institute of Purpan, Toulouse, F-31059 France; 5 Department of Experimental Medical Science, Division of Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden 20 6 Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
منابع مشابه
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.
Hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) regulate adipocyte lipolysis in rodents. The purpose of this study was to compare the roles of these lipases for lipolysis in human adipocytes. Subcutaneous adipose tissue was investigated. HSL and ATGL protein expression were related to lipolysis in isolated mature fat cells. ATGL or HSL were knocked down by RNA interference...
متن کاملAltered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
OBJECTIVE Insulin resistance is associated with elevated content of skeletal muscle lipids, including triacylglycerols (TAGs) and diacylglycerols (DAGs). DAGs are by-products of lipolysis consecutive to TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL). We hypothesized that an imbalance of ATGL relative to HSL (expression or a...
متن کاملChanges of Hormone Sensitive Lipase, Adipose Tissue Triglyceride Lipase, and Free Fatty Acids in Subcutaneous Adipose Tissues throughout the Ripening Process of Dry-cured Ham
and Implications Changes in adipose triglyceride lipase (ATGL) and hormone sensitive lipases (HSL) in subcutaneous adipose tissue of Xuanwei ham at different ripening stages were studied. Green hams were salted for 40 d and then ripened in a ventilated chamber for 15 months. Adipose triglyceride lipase and HSL could be detected during the whole ripening period of Xuanwei ham, but their protein ...
متن کاملOmental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome.
BACKGROUND Elevated free fatty acids (FFAs) are involved in insulin resistance in polycystic ovary syndrome (PCOS). We investigated the role of fatty acid transporter CD36, hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) in regulation of lipolysis in insulin-resistant women with PCOS. METHODS CD36, HSL and ATGL proteins were analyzed in omental adipose tissue from 10 wom...
متن کاملBreed difference and regulation of the porcine Sirtuin 1 by insulin.
Sirtuin 1 (Sirt1) plays an important role in fat metabolism. In the current study, we examined the breed differences in Sirt1 between Jinhua pigs (a fatty breed of China) and Landrace pigs (a leaner breed). In addition, the effect of insulin on the gene expression of Sirt1 and the major lipase, adipose triglyceride lipase (ATGL), and hormone-sensitive lipase (HSL) in fat metabolism was also stu...
متن کامل